Its Time to Stop Animal Research, Testing, and...

Its Time to Stop Animal Research, Testing, and Experimentation Using animals in research and to test the safety of products has been a topic of heated debate for decades. According to data collected by F. Barbara Orlans for her book, In the Name of Science: Issues in Responsible Animal Experimentation, sixty percent of all animals used in testing are used in biomedical research and product-safety testing (62). People have different feelings for animals; many look upon animals as companions while others view animals as a means for advancing medical techniques or furthering experimental research. However individuals perceive animals, the fact remains that animals are being exploited by research facilities and cosmetics†¦show more content†¦Risks are not morally transferable to those who do not choose to take them (qtd. in Orlans 26). Animals do not willingly sacrifice themselves for the advancement of human welfare and new technology. Their decisions are made for them because they cannot vocalize their own preferences and choi ces. When humans decide the fate of animals in research environments, the animals rights are taken away without any thought of their well-being or the quality of their lives. Therefore, animal experimentation should be stopped because it violates the rights of animals. Next, the pain and suffering that experimental animals are subject to is not worth any possible benefits to humans. The American Veterinary Medial Association defines animal pain as an unpleasant sensory and emotional experience perceived as arising from a specific region of the body and associated with actual or potential tissue damage (Orlans 129). Animals feel pain in many of the same ways that humans do; in fact, their reactions to pain are virtually identical (both humans and animals scream, for example). When animals are used for product toxicity testing or laboratory research, they are subjected to painful and frequently deadly experiments. Two of the most commonly used toxicity tests are the Draize test and the LD50 test, both of which areShow MoreRelatedAnimal Experimentation Is The Cruel Silent Animal1349 Words   |  6 PagesAnimal Experimentation No doubt, we all love our products whether it be beauty, medicinal, or cleaning purposes. Of course they satisfy our needs and maybe even go above and beyond and just make the smallest difference or the biggest in our lives by improving or making things easier. Ever wonder how these products go about being made? Probably not. This however is something we should consider paying close attention to. Behind the scenes of our most favorite products is the cruel, silent methodsRead MoreAnimal Experimentation And The Early Greek Era1716 Words   |  7 Pages1101 9 November 2015 Animal Experimentation: We Owe It to Them Animal Experimentation has been dated as far back as to the Early Greek Era. This practice has been viewed as ethical by research scientists trying to find new medical breakthroughs. Yet, in recent years, the use of animals in research and experimentation has been frowned upon by animal protection groups and animal rights activists. Animals are protected by certain guidelines and ethics prior to their use in research. Contrary to popularRead MorePersuasive Essay On Animal Rights1526 Words   |  7 PagesAnimal testing has been one of the issues that people are fighting overtime because of its moral. Even though some results of tests are successful on people, many people are still fighting for the animal’s rights. They believe that animals should have their own rights to live a free life where they belong, just like their species. In scientists point of view, animals have been one of the main subjects to test on, but a lot of them are currently looking forward to use and deve lop alternatives forRead MorePersuasive Essay On Animal Testing1155 Words   |  5 PagesAnimal Testing Animal experiments happen all over the world, but are they necessary? Animals are tested for medical research as well as for cosmetics. Some say that these experiments are not painful, so they are justified. Where others believe that all these experiments are inhumane and nothing can justify torturing and killing innocent animals. Although many believe that animal testing is the best way to improve human health by finding new treatments and tests for the safety of the productsRead MoreArgumentative Essay On Animal Testing1485 Words   |  6 PagesThis is just a couple examples of the pain and suffering animals go through while being experimented on. Experimentation can be defined as a process that performs a scientific procedure that usually takes place in the lab to dictate something. Animal experimentation is unethical because of the many terrible tests conducted, it’s cruel, animals are equivalent to humans, and it’s not necessary. Animal testing has been around for a long time. Going all the way back to 384 - 322 BC, an early GreekRead MoreAnimal Testing Should Stop Testing Their Products On Animals1722 Words   |  7 Pageshistory, animal experimentation has played a significant important role in leading to new discoveries and human benefit. However, what many people tend to forget are the numbers of animal subjects that have suffered serious harm during the process of experimentation. Each day across America innocent animals are used as test subjects for products that have little to no relevance importance. Animal testing has had many negative issues arise in society in a negative way. Debating over the animal rightsRead MoreEssay about Animal Testing is Unethical1385 Words   |  6 Pageswhen you eat or what you eat, how you will spend your time, whether or not you will have husband or wife or children, and if you do, who that person will be. You cant even decide when the lights go on and off. Think ab out spending your entire life like this, even though you didnt do anything wrong or commit a crime. This is life in a laboratory for animals. It is deprivation, isolation, and misery. Now think about the needs of the animals that are caged up and stripped away from their naturalRead MoreAnimal Experimentation Essay1307 Words   |  6 Pagesanother victim of animal experimentation. While there are some benefits of testing animals for medical purposes, there are also alternative means that are possible and could be even more effective. Scientists and researchers around the world claim that many people owe their health to animal research. Several noteworthy medical advancements, such as the polio vaccine, insulin for diabetes, and antibiotics for pneumonia, have been said to have not been possible without the use of animals (Hurley n. pag)Read MoreAnimal Testing Should Not Be Banned923 Words   |  4 Pages statistics show that each year more than ten million animals are â€Å"killed in U.S. laboratories for biology lessons, medical training, curiosity-driven experimentation, and chemical, drug, food, and cosmetics testing.† It’s no surprise that animal testing has caused a lot of controversy in the world throughout the past few years. Vegans and Omnivores tend to go head to head over the rights of animals. Some people even question if these animals should even have rights at all, while others believe thatRead MoreThe Use Of Research On Cosmetics And Its Effects On Society1604 Words   |  7 PagesB linded by Beauty On average, 26 million animals are used every year for the use of research on cosmetics. These tests should be banned for many obvious reasons such as it is clearly cruel and inhumane, they cost more than alternative methods, and they do not predict an accurate result due to the anatomical differences. Animals are being unfairly tortured and killed for research on ingredients that people are unknowingly using in their everyday lives. Here’s an important question to consider;

Data Warehouse Free Essays

The Kimball Lifestyle is the recommended approach to design, develop deploy he DO/BI, as described in aforementioned text book (eBook). The illustration at Figure 1 summarizes main stages from the Lifestyle. Figure 1: The Kimball DO/BI Lifestyle The Kimball method helps to explain business requirements adding value to an organization. We will write a custom essay sample on Data Warehouse or any similar topic only for you Order Now The company must realize this value add, acknowledge it and then decide to implement the solution. (MS. Com, n. D. ). Issues and Process involved in Implementation of DO/BI system Dimensions Business Processes Date Transaction Client outlet Category Type Product Venue Budget Events_organize x Celebrity Booking Advertisement Books Sale Book Distribution Commission payment The Data Warehouse Bus Matrix The main process involved is the development of the Data warehouse Bus Matrix, as it was highlighted in the earlier section. The Enterprise Data Warehouse Bus Matrix is the data framework for the enterprise data warehouse. The Figure below shows the bus matrix for Jar Bookstore: Data Model Design The Kimball method provides practical approach land selects the right physical model based upon how usable and flexible it is and how is its performance maintenance. Almost all these type of models are classic star schemas, as shown in Figure 3. The complete information of a process is its central fact table. Its like a first normal form or ‘De-normalized’ dimension tables, which surrounds the fact table. Then there are details or dimension tables which can be joined with integer keys called ‘surrogate keys’. This is shown in the below figure. Some researchers call for the normalized, third normal form model at lowest level in data warehouse as this provides Max flexibility. The dimension or detail table bear an analogy to this as will be shown in the subsequent analysis in the later sections. (MS. Com n. . ) Figure 3: An orders business process star schema Star Schema Model Here is a design of star schema, with clear dimensions with Primary an Foreign Keys. As per the Kimball Method, the star schema represents the Normalized Source Tables. As per the model, the â€Å"dimensions are the objects that participate in an organization’s business processes. We generally model these as one table per object. Building the dimension in the TTL system involves joining the various normalized description and hierarchy tables that populate the dimension attributes and writing the results into a single table. (Thorniest, W, 201 1) RED Diagram to provide a complete overview of the Online Bookstore. Data warehouse requires designing Fact tables and dimension tables. As provided earlier the fact table is the central table within star schema of a data warehouse. A fact table contains basic, raw and De-normalized data. For the Jar Bookstore there are three types of facts: (Thorniest, W, 2011) 1. Additive: these are summed up data 2. Semi-Additive: Semi-additive facts that can be summed up for some data only 3. Non-Additive: Non-additive facts are facts that cannot be summed up. In the context of Jar Bookstore we illustrate each these three types of facts. The first example assumes that we are a retailer, and we have a fact table with the follows Eng columns: Date Store Sales Amount This table records the sales amount for each product in each store on a daily basis. This data is extracted in the excel sheet as well and will be analyzed in the later sections. The Jar Bookstore has the following fact table: Date Books Current Balance Profit_Margin The object of this table is to record the current balance for each account at the end of each day (DOD Balance). How to cite Data Warehouse, Papers

Future of English free essay sample

Future of English as a global language â€Å"A language achieves a genuinely global status when it develops a special role that is recognized in every country† (Crystal 1997). In the 21st century, English is increasingly becoming the dominant language in global communication. However, the question of where the future of English lies remains unclear. Will English in the future increase in popularity or should we adopt a better alternative? English is undoubtedly one of the most influential languages in the world as more and more people use English as their official or second language. It has been given a variety of labels to represent its popularity. However, social inequalities and injustices have also emerged in the same process, revealing the controversial role English has had internationally. In order to critically examine the future of English as a global language this essay will discuss the following topics in this literature review. 1. Rise of English World-wide 2. We will write a custom essay sample on Future of English or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page English as the language of Science and Technology 3. English language teaching world-wide The number of English speakers in the world has increased at an astonishing rate throughout the last few centuries. According to Crystal he states that by 1983, the number of people speaking English as an official language was over 1,400 million world wide. Moreover in India and its subcontinent, the English language has an official standing. In the late 1990’s the number of English speaking citizens in China was approximately 220 million. The Olympics provided the motivation for an increase to double these numbers. English has brought benefits, social inequalities and injustices. It remains questionable as to whether or not English would remain a global standard language. Tsuda discuss how the political and cultural neutrality of the common language used internationally is extremely important and is required within the English language. By incorporating English into any society, countries are able to have some share of the globalization benefits but this necessitates the force of implementing English. If this way is adopted, the independence and uniqueness of other cultures will diminish because of one language dominating other ways worldwide and homogenize them into a Western and more particularly an American way of life. Esperanto has been suggested by Tsuda is a language that could be used for the purpose of an equal communication. The Esperanto movement has its philosophy as peace. The author questions whether English has a similar philosophy. THE RISE OF ENGLISH WORLD ·WIDE English has undoubtedly dominated other languages in the past 20 years. How it came to be so is another story altogether, although some stress it on historical or political spurs while others believe that modern-day socio-economic and scientific motivations led to its popularity. However in my opinion and with some research it is believed that the popularity of English began by the end of World War II. The only major industrialized country unaffected by war was the United States. The United States rapidly began working on scientific discoveries, such as the computer, this led to an increase in exchange of information globally, by design English became the source language for storage of information and its retrieval. The United States spent 40 years, after the war, working on setting up research universities, research and development departments, economic stability and computer networking. Hence becoming the supreme user of information technology as well as its biggest contributor. When you contribute towards something you eventually become its manager, similarly the United States began managing information such as its categorization, storage as well as operating languages and computer system designs. And the only medium it knew best to manage was in the programmer’s natural language i. e. English. So now English not only became the global language of Science but also ecame the global language of Information Technology. The position of English as a dominant language in areas of science and Technology is now quiet secure since most of the modern-day information assemblage are English based. English as the language of Science and Technology: Over the last 20 years, the spread of English has been enormous. Developing Countries desires for economic development, their need for information access and transfer of technology have been the key catalyst behind this domina nce. Although some might see this dominance as a negative impact that will not last for long, in Baileys 1983 article he states: â€Å"People bent on imposing their ways on others have no difficulty in contriving arguments to justify their doing so. The historical and present-day spread of English is no exception to that principle. Also â€Å"The hegemony of English that has steadily grown with the increase in global communication is now beginning to diminish and will shrink further in the immediate future† Although such a notion puts forward that English does represent part hegemony, it is the sort of hegemony that will not fade away or diminish in the near future due to some revolution but if it does it will not be as most have expect. However if evidence to date is considered, English is far from being diminished, it is now more than ever still expanding and continuing to secure its role as a global language hence further emphasizing the importance of English in our modern day lives. It should be made clear that any country that wishes to modernize itself and grow in the areas of science and technology and eventually com pete in global markets cannot show a resistance towards English. It is imperative for any country wishing to make its place in the world for any form of trade to communicate in English. Such will be the case until a time comes in the future when other languages are able to provide access to larger information and better technological development, or until a computer’s ability is developed to such an extent that it becomes independent of any specific natural language. Many have termed this statement as an argument for English for Science and Technology (EST) instruction. Of late Garfield (1987) pointed out that 88% of articles present in the Science Citation Index were in English, and from 1978 till 1982 data indicates that this development has been quiet consistent. He further adds that if citation data is to be considered then the dominance of English is seen at large. Around 96% of all citations, from 1978 to 1982, present in the index journal are written in English. Garfield also surveyed that most countries that had an option to publish in their language or a foreign language often chose to publish in English as frequently as in their own language. For example according to Garfield’s research, from 1978 to 1982, the Japanese Scientists cited their own publications 3 times as much as their Japanese publications. While according to Swinburne (1983) the French scientists cited their publications in English four times as much as their French publications. In the same way the Russian Scientists cited their publications quiet often in English as well. All this suggests that even those countries that value their natural language more are now giving a lot of importance to the use of English as a global language as well as a medium for scientific progression. The major reason behind this acceptance of English is due to the fact that 80 to 85% of all information stored in a computerized data bases around the world are written in either English or in some way abstracted in English. (Kaplan 1980-1982) and (McCrum et al 1986) English is not only the language for Technology but now is widely being used in Medical publications, in a study by Maher(1986) it is pointed out that from 1966 to 1980 a 19% increase in use of English in medical publications can been seen, from 53% to 72% respectively. In more recent research Maher shows that, with Japan being an exception, there is an incline towards the trend in general rather than a decline. English is undoubtedly the prevailing and widely used language of Science and Technology. Therefore it must be understood that for any country to ecome modernize and industrialize and technologically competitive, it is imperative that they access or use information that has been written in English. In the past 20 years the exponential growth in publications, the need for even faster retrieval and access of information and the stark demands generated by private multinational corporations and government industries have created a competition amongst countries to an extent that t he only access to information they have, technological or otherwise is basically in English. So any public or private modern day business or industries wanting to compete in the global markets and magnify their production need to have access to some form of information, latest researches and technological applications. And in order to utilize the research, applications or information the managers or administrators must be able to use English because English will be the language used to acquire information out of a system. This competition and the need for latest information make the position of English as a global language unwavering and steadfast for years to come. According to Forey Nunan â€Å"Hong Kong is a major international trading, business, banking, and communications center, and English is seen as a key to maintaining its position in these areas. †(Forey Nunan, 2002) ENGLISH LANGUAGE TEACHING WORLD ·WIDE In extension to the above rationale that English is the language of Science, it won’t be wrong to say that wherever a need exists English is to be taught. Over the past 20 years this awareness has grown world-wide and more and more countries are giving English a great deal of importance in their school curriculum. Although the level of English being taught and the measures to be taken for its proper learning is a different issue altogether. Asian countries like China, Honk Kong, Taiwan, Korea, Philippines and Malaysia have added English language in their school curriculum at an early age, with teaching time ranging from minimum 4 hours a week to maximum 50 hours a week. Also a shift in the age at which English is taught is seen, from secondary classes to primary classes. It should be made clear that not all citizens of a country need to understand English, although in doing so they are denying themselves the access to the enormous information available world-wide. Even a country like Japan that holds a strong resistance towards English has introduced the language at high school level. English in China is in some way considered or has become the language for the elite; those who are unable to learn proper English in schools and have a sound family background begin taking private tuitions in order to learn English. This introduction of English in schools at such primary level, as well as the steps various governments have taken to ensure its proper learning of the language simply shows the dominance and importance of English world-wide. CONCLUSION To draw a conclusion that English is indeed a global language and will likely remain one in the near future seems reasonable. English plays a vital role is areas of information retrieval and its access, as well as in Science and Technology. Any country wishing to explore or expand in these areas will need to understand English. Although coming to such a conclusion is not as simple as it may seem, there are many complex issues at stake here but nevertheless, in light of the evidence provided in this paper it will not be wrong to say that English has clearly achieved world dominance and will continue to maintain its position not only as the language for Science and technology but also as world language in general. As Kaplan (1983b) has noted in an editorial in Science: â€Å"It seems reasonable to assert, however difficult it may be to accept, that knowledge of a world language, especially English, is essential to the welfare of the new nations . . New nations must find a balance between the cultivation of indigenous culture-rich language and the need for a world language . . . Any other course is tantamount to restricting their capability for modernization. † Reference List ? Bailey, R. W. (1983) Literacy in English: an international perspective. In Literacy for Life. Edited by R. W. Bailey and R. Fos heim. New York: MLA. pp. 30-44. ? Crystal, D. (1997). English as a global language. Cambridge: Cambridge University Press. ? Crystal, D. (2000). Language death. Cambridge: Cambridge University Press. Curriculum Development Council. (1999). Syllabuses for secondary schools Englishlanguage (Secondary 1–5). Hong Kong, Special Administrative Region, China: Hong Kong Education Department. ? Education Commission. (1990). Education commission report number 4. Hong Kong, Special Administrative Region, China: Hong Kong Education Department. ? Forey, G. , Nunan, D. (2002). The role of language and culture within the accountancy workforce. In C. Barron, N. Bruce, D. Nunan (Eds. ), Knowledge and discourse: Towards an ecology of language. London: Longman/Pearson. ? Garfield, E. (1987) English spoken here. The Scientist, 1, 9 (7 September). ? Graddol, D. (1997). The future of English. London: British Council. ? Kaplan, R. B. (1980) A language-planning rationale for English for special purposes. In Language Policy and Language Teaching: Essays in Honor of Clifford H. Prator. Edited by J. Povey. Culver City, CA: ELS. pp. 53-64. ? Kaplan, R. B. (1982) Information science and ESP. Paper presented at the 16th Annual TESOL Convention, Honolulu, HI, May 1982. Kaplan, R. B. (1983b) Language and science policies of new nations. (Editorial) Science, 221,4614 (2 September). ? McCrum, R. , Cran, W. and MacNeil. R. (1986) The Story of English. New York: Viking. ? Maher, J. (1986) The development of English as an international langiage of mine. Applied Linguistics, 7, 206-218. ? Swinburne, J. (1983) Information use and transfer by British and French scientists: a study of two groups. Journal of information science 6, 75-80 2010

Picassos The Guitar Player Essay Example

Picassos The Guitar Player Essay There is no abstract art. You must always start with something. Afterward you can remove all traces of reality, quoted by Pablo Picasso, represents how his art moves away from realism and the traditional views of art in pre modernist era (Picasso). Picasso is known for his abstract paintings and is described as a modern artist. Ideas expressed in the handout Modernism are used to describe Pablo Picassos The Guitar Player (1910) and are used to define the painting as a modern work of art. The dimension created through the use of cubism and subjective style expressed in Picassos The Guitar Player defines the painting as a modern The Guitar Player is a cubist painting that moves away from the traditional design of a painting by presenting an uncertain image not found in the natural world. The title of the painting is the only indication of what is being presented.Lines used to create a person and a guitar become confusing, as evidence of the existence of the objects becomes blu rred. Monotone colors, shadowing, and shapes help add depth to the image. The depth developed creates multiple points of view. It removes the flatness of pre modern painting by giving the appearance of three-dimension to the painting. The dimensionality created is not normally The abstract and unnatural image defines the painting as a modern art piece. Cubism is an art about art, instead of being a mirror image of the exterior world. It is art referencing other art. The painting isnt a representation of what can be found in the exterior world, it is a representation of what is found within the artist (Edward). The painting is not objective, but subjective. The lines, shapes, color and shadowing are used to represent the artist;s inner thoughts and emotions. There is no narration or instruction found within the painting. It is different from pre modern ar

photography evolution through eps cycle elitepopularsocial essays

photography evolution through eps cycle elitepopularsocial essays In 1839 a process was invented that would forever change human perception and communication. Dubbed photography from the Greek words phos meaning light, and graphos meaning writing (Jeffrey, 240), the process was a much anticipated discovery. Long before its actual birth, the basic concept of of photography was common knowledge. It wasnt until the 1800s, however, that the idea of permenently fixing an image to a surface became tangible. Upon this discovery came the race to create the photograph. Encoureged by a very eager middle class, early photography had many expirimentors. Two of which are credited as the fathers of the invention. Both of these fathers created photography simultaneously in 1839, announcing their success within three months of one another. Although each of these inventors imployed different techniques, the overall effect was the same, a permanently fixed photographic image. The first of the two technologies was the work of Louis Jaques Mande Daguerre. His method of photography incorporated the use of copper plates covered in light-sensitive chemicals as printable surfaces. Both the weight of the plates, as well as the availability of the chemicals kept photography out of the hands of the middle-class. This elite status, however, was short lived. Photography was the direct result of a demanding middle class causing a push for both inexpensive materials as well as simple devices. Photography did not spend much time in the elite stages of society. Instead the medium quickly evolved to accomodate a very eager public. Only ten years after its invention, a society of photographers was formed, organizing a profesion that was now becoming a fad. As one photo-historian explains: by 1851, pictures supplemented names, and identity became a matter of images rather than words (Jeffrey, 241). Specialization of the medium took many forms, but it wasnt until 1880 that the most bla...

Anna Karenina by Leo Tolstoy (1828 †1910)

Type of Work: Tragic love storySetting Moscow and St. Petersburg, Russia; nineteenth century Plagiarism Detection >Principal Characters Robert Jordan, an American fighting with Spanish Loyalists Anna Karenina, a beautiful young woman Alexey, her cold, vindictive husband Count Vronsky, a young military officer who falls in love with Anna Stepan Oblonsky, Annas spendthrift brother Dolly, Stepans frustrated wife Kitty, Dollys sister Levin, Stepans rusticc friend, and Kittys suitorStory Overveiw Stepan Oblonskys wife Dolly had discovered that her husband was having an affair. With her beauty fading and her household a wreck, she had had enough. Stepan fretfully wrote to his sister, Anna Karenina, asking her to come to Moscow and convince Dolly not to leave him.Later, while working at his job in the entrenched Moscow bureaucracy, Stepan received an unexpected visitor: Levin, an old friend from the university, came to discuss Dollys sister Kitty, whom he wanted to marry. After being inform ed by Stepan that he had a rival for Kittys affections, a certain Count Vronskv of St. Petersburg, Levin resolved that he would propose to Kitty that very night.At that same moment, Anna and Count Vronsky were riding together in a train bound for Moscow. Vronsky noticed the charming woman as he made his way to the first-class compartment that he shared with his mother. He had time to take note of the suppressed eagerness which played over her face as their eyes met, and she remained in his mind. However, upon reaching their destination, the two went their separate ways Anna to her brothers home, Vronsky and his mother to a hotel.Approached by Anna, Dolly at first refused to discuss her husbands infidelity. Everythings lost after what has happened, evervthinqs over! she raged. But finally she relented to Annas plea to keep the family together.Meanwhile, Levin had arrived early at a dinner party hosted by the parents of Kitty and Dolly, determined to make his desires known to Kitty b efore the appearance of the rich and handsome Count. But That cannot be forgive me, Kitty replied upon hearing his stammering proposal. Crushed by the rejection, Levin escaped from the gathering at the first opportunity.A few days later, at her coming-out ball, Kitty couldnt help but notice how Anna and Vronsky kept gazing at each other. Vronskys face had a look that puzzled her . . . like the expression of an intelligent dog when it had done wrong. It was clear to Kitty that the two were in love.Nevertheless, with her task of seeing to Stepan and Dolly completed, Anna boarded the next train for St. Petersburg. She thought of her son, Seryozha, and her husband, Alexey.. Mv life will go on in the old way, all nice and as usual she thought. But she found that she could not easily dismiss Count Vronsky from her mind. And stepping along the way, as Anna stepped out for a breath of air, there he was. You know that I have come to be where you are; I cant help it, confessed the officer. Anna was both delighted and flattered by this, but it was simply unthinkable that anything could come of his attraction to her. After all, she was a married woman.Back in Moscow, Kitty was devastated. Not only had Count Vronsky spurned her, but Levin had also left the city to supervise work on his country estate. Humiliated and distraught, Kitty became so ill with despair that she was soon unable to eat or sleep. Her frantic parents, after finding no restorative medical treatment in Moscow, sent her to Europe to consult various doctors.Meanwhile, life for Anna in St. Petersburg remained strangely unsettled. The happiness that in Moscow had fairly flashed from her eyes, [now seemed] hidden somewhere far away. To her further disquiet, the love-struck Vronsky took every opportunity to see her. One night she knelt and begged him to leave her in peace; but still he persisted: I cant think of you and myself apart. You and I are one to me. And at that moment Anna let her eyes rest on him, full of love.Soon afterward, Alexey Karenina walked into a party and found his wife with Vronsky; but Anna denied any impropriety. Still, she and Vronsky met night after night, with Alexey seemingly powerless or unwilling to stop them. Anna by now felt so sinful, so guilty; but still she could not curb her passion for the Count.The following summer, while staving at her husbands villa outside the city, Anna confronted her lover with an announcement: she was pregnant. Though he understood the gravity of Annas position, Vronsky smiled. This was the turning point he had been longing for.Leave your husband and make our life one, he implored. But Anna shook her head. If she left, Alexey would take sole custody of Seryozha and she would not be allowed to see her son. But Anna did promise Vronsky that she would tell her husband the truth about the child she was carrying.When Anna made her confession, Alexey, instead of showing jealousy or indignation, merely warned his wife against public displays of flirtation. His sole concern was to preserve his social and business reputation; a duel or a divorce would only serve to disgrace him. The family cannot be broken up by a whim, a caprice, or even by the sin of one of the partners in the marriage, he informed Anna Our life must go on as it has done in the past.Anna reacted to his words at first with guilt and shame, but this quickly turned to anger: He knows that I cant repent that I breathe, that I love; he knows that it can lead to nothing but lying and deceit- but he wants to go on torturing me . . . Vronsky also was increasingly anxious to begin a new life with Anna, who would not leave her son. And so, the position was one of misery for all three Kitty had by now returned to Moscow, feeling somewhat better. One morning, just after dawn, Levin caught sight of her in a carriage, as it skirted his estate destined for her familys summer home. The pangs of love, long since buried, welled up in him once more. Months late r, taking advantage of a trip to the city, he called again upon Kitty. It was apparent to both that they cared deeply for each other, and, after a proper courtship, they were united as man and wife. Levin, for years caught up in trying to find out who he was and where he fit in Gods universe, had finally and happily found his place.But in St. Petersburg, relationships were breaking up. The nearer Anna came to the birth of her child, the more demanding and cold Alexey became. Then Anna survived a deadly fever to give birth to a baby girl. Oddly, the difficulty of the birth eased the tensions between herself and her husband. At the other extreme, Vronsky saw no end to the barriers separating him from his lover. Desperate at the prospect of living without Anna, he unsuccessfully tried shooting himself. Still torn, Anna finally did move in with him, and soon the couple left Russia to live in Italy for a time.Meanwhile, Kitty and Levin were living on their estate outside of Moscow. Levin felt gratified to be spiritually sustained by a loving wife. Like Anna, Kitty went through a difficult pregnancy, but it culminated in the birth of a fine little boy. Theirs was an idyllic life.Upon returning from Italy to St. Petersburg, Vronsky and Anna, found themselves ostracized. Gossip followed them everywhere. The couple argued frequently, and Anna, in a burst of depression, finally accused Vronsky of being unfaithful. Even after they moved into a newly-inherited estate, Anna felt alone in the world. She revived her habit of taking a little morphine to help her sleep, a legacy from her pregnancy.Summer turned to winter, and the family relocated again, this time to Moscow. There, the badly strained relationship fared no better. Though Anna pled for Vronsky to love her and give her security, at the same time she increasingly insisted on greater freedom. This is becoming unbearable! Vronsky screamed one day. Why do you try my patience? It has limits. Anna could only gaze at him with terror at the undisguised hatred in his whole face. Vronsky checked himself: I mean to say I must ask what it is you want of me? All I want, she replied, is that you dont desert me, as you think of doing . I want love, and there is none. .. Vronsky vainly protested; he would never cease to love her.Suddenly, Anna turned on Vronsky, cursing him for the sacrifices she had made to be with him her marriage, her son, her social position Delirious with bitterness, Anna had no place to turn; Vronsky, she was convinced, had found another, and she could never return to Alexey. Ambling into the train station, she purchased a ticket. Then, standing on the platform, watching the trains, she said to herself.. I will punish him and escape from everyone and from myself.Measuring both the speed of the oncoming train and her resolve to end her suffering, she jumped. Something huge and merciless struck her on the head and rolled on her back. Lord, forgive me all!Anna Karenina was dead.Comme ntary Leo Tolstoy is considered one of Russias greatest nineteenth-century novelists, an honor he shares with Dostoievsky. Tolstoy, however, focuses his novels on the vicissitudes of the upper-classes rather than on Dostoievskys underprivileged peasants or criminals. Plagiarism Detection >Tolstoy foresaw the end of the aristocracy in Russian society. Serfs had already been set free; the working class was beginning to expand in power. Moreover, new mores and morals were being imported from the West, and societys upper crust was the first to feel the strain of these changes a strain running an undercurrent throughout Anna Karenina.The novel reads like a soap opera, with the exhaustive cast of characters continually creating their own problems. Contrast Annas tragic quest for love and personal fulfillment with the spiritual odyssey of Levin. Through hard work and the support of an understanding family, his search is rewarded by happiness. Thus, Tolstoys gripping masterpiece revolves a round the dissimilar paths of these two characters, allowing a forum for the authors commentary on Russias maze-like social system, fraught with unresolved incongruities.

Molecular Mechanisms of Atrial Fibrillation Essay

Molecular Mechanisms of Atrial Fibrillation - Essay Example Progression in the studies of genetics and molecular biology would assist in dealing with this disease in a better way. Recently studies by Chelu et al (2009) have brought into light the fact that differences in the ionic (mainly Ca 2+) current flow are responsible for causing AF and turning it into a chronic condition. As Brugada points out â€Å"Research efforts to elucidate the molecular basis of AF are focused into two main areas: human genetics and alterations in genetic expression of ion channels† (Brugada, Is Atrial fibrillation a genetic disease?: Molecular Mechanisms in Arial fibrillation). The beating of the heart muscles, according to research, is strictly controlled by a procedure known as ‘Ca 2+ induced Ca 2+ release’. Here we find that the number of Ca ions that are entering through the Cav. 1.2 which is the L type voltage gated Ca ion channel helps in the increase of the release of more Ca ions from the sarcoplasmic reticulum through the intracellular Ca 2+ channels (ryanodine receptor type 2 or RyR2). This influx and release of Ca ions are strictly regulated by the heart muscles for the controlled beating of heart. In AF, where the atria beats rapidly, this rapid beating of the heart leads to production of more Ca ions or Calmodulin- dependent protein kinase II ( CaMKII) phosphorylation of the RyR2. In AF conditions it has also been noticed that L type voltage gated Ca ion channels show a decrease in its amplitude, so it has been deduced that this release of the Ca ions may be due to enhanced functioning of RyR2 channels. There are many reasons as t o why the RyR2 channels may function differently. Earlier it was seen in researches conducted on dogs showing AF conditions, that RyR2 channels remained open in cases having low cystolic Ca ion presence. Another reason as Vest, et al, tells us from his experiments into molecular mechanisms that â€Å"SR Ca2+  leak due to RyR2